Lysosomal acid lipase deficiency (LAL-D) is a rare genetic disorder with two clinical variants: Wolman disease in infants and cholesteryl ester storage disease in children and adults. Sebelipase alfa, a recombinant human LAL, has been evaluated for its safety and efficacy in treating LAL-D. A systematic review of seven records from five studies involving 110 patients showed significant improvements in serum transaminases and serum lipids, though changes in gamma-glutamyl transferase and liver volume were not significant. Adverse events were mostly mild-to-moderate. Sebelipase alfa is concluded to be an effective and well-tolerated treatment for both variants of LAL-D.

The article emphasizes the importance of understanding the roles and responsibilities of various mental health professionals to ensure proper mental health care. It details the qualifications, specializations, and functions of different professionals such as psychiatrists, clinical psychologists, counselors, psychiatric nurses, psychiatric social workers, occupational therapists, and special educators. The authors stress the need for public awareness to avoid misconceptions and ensure that individuals seek the appropriate professional help for mental health issues.

Doctors in Amritsar, Punjab, conducted a five-hour surgery to remove 40 knives from the stomach of Jarnail Singh, a 42-year-old man who initially complained of low appetite, weight loss, and stomach pains. Dr. Jitendra Malhotra, one of the surgeons, expressed astonishment at the case, noting it was unprecedented in his career. The patient had swallowed the knives over two months, and there are concerns about his mental health.

Batuli Lamichhane, a 112-year-old woman from Nepal, attributes her longevity to smoking 30 cigarettes a day for the past 95 years. She advises against commercially made cigarettes, recommending locally made 'beedis' instead. Despite her age and the challenges she has faced, including the loss of her home in an earthquake, Batuli remains active and self-sufficient. She believes that staying active, stress-free, and happy are key to a long life.

Jagwinder Singh, a 24-year-old armless art teacher from Patran, Punjab, has set his sights on Paralympic glory after discovering his talent for cycling. Inspired by the London 2012 Olympics, he began cycling 25km to Patiala three times a week. With the support of his family and friends, he now aims to compete in the Paralympic Games, serving as a source of inspiration in his community. Despite his parents' concerns about his future, Jagwinder remains focused on his training, aspiring to win a gold medal and make his country proud.

The parents of Jyoti Singh, a 23-year-old medical student who was raped and killed in Delhi in 2012, express their dismay at comments made by one of her attackers in the BBC documentary 'India's Daughter.' The documentary, which has been banned in India, features Mukesh Singh blaming the victim for the attack. Jyoti's parents, Badrinath Singh and Asha Devi, criticize the lenient treatment of one of the juvenile attackers and call for stricter rape laws in India. The article highlights the ongoing issue of rape in India and the need for judicial reform.