Marcos López de Prado, a faculty member at Cornell University and CEO of True Positive Technologies, will present a keynote at the ACM Conference on Artificial Intelligence in Finance. His talk will cover the unique opportunities financial machine learning offers, such as extracting non-linear relationships, analyzing unstructured data, and controlling for statistical overfitting. Key applications include price prediction, hedging, portfolio construction, and outlier detection. López de Prado emphasizes that effective machine learning in finance requires significant insight and care.

DeepMind, a research subsidiary of Alphabet, has developed new sorting algorithms through its AlphaDev system, achieving significant efficiency improvements. This follows their previous successes with AI programs like AlphaGo, AlphaFold, and AlphaTensor. The new algorithms have been integrated into the LLVM standard C++ sort library. The article also discusses the broader implications of AI advancements, including potential societal impacts and the ongoing debate about the risks and benefits of artificial intelligence.

Marcos Lopez de Prado and Alexander Lipton present a new mathematical model (K-SEIR) to evaluate various exit strategies for COVID-19 lockdowns. They argue that universal lockdowns, while effective in saving lives, have caused significant economic and social harm, particularly to minorities and the working class. The K-SEIR model aims to help governments implement more targeted lockdowns that balance saving lives, protecting the vulnerable, and preventing the depletion of medical resources. The authors emphasize the need for tailored strategies based on national circumstances to better prepare for future pandemics.

Seasonal Affective Disorder (SAD) is a serious condition linked to sunlight exposure, and light therapy can help mitigate its effects. Dr. David Bailey has updated his guide on the best SAD light therapy products, highlighting options like the Luminette 3 SAD Light Visor for its comfort, convenience, and affordability. Other products reviewed include Moodozi light therapy lamps and Caribbean sun therapy lamps, catering to various needs and budgets.

The MacKinnon Lists Technique (MLT) is proposed as a new method for rapidly assessing biodiversity and species abundance in marine environments, particularly in species-rich habitats like coral reefs. The study compares MLT to the widely used MaxN method, finding that MLT generates comparable results in terms of species richness, diversity indices, and relative abundance. MLT is highlighted for its cost-efficiency, simplicity, and ability to produce stable estimations with lower sampling effort. The technique is suggested to be useful for rapid conservation assessments and could complement existing methods like MaxN for more comprehensive biodiversity monitoring.

The article critically examines the probability arguments used by creationist and intelligent design proponents to refute evolution. It highlights the fallacies and errors in these arguments, such as unrealistic probability models and the post-hoc probability fallacy. The text underscores that biological evolution is not a random process and that natural selection plays a crucial role. It also presents examples from scientific research, including studies on hemoglobin, RNA nucleotides, and recent human evolution, to demonstrate the validity of evolutionary processes. The article concludes that creationist probability arguments lack empirical support and should be viewed with skepticism.

Johann Sebastian Bach, while not formally trained in mathematics, is celebrated as a 'mathematician' among classical composers due to the intricate patterns, structures, and recursions in his music. His vast body of work, including over 1,100 compositions, exhibits mathematical elements such as Fibonacci numbers and the golden ratio. The article explores the relationship between mathematics and music, citing examples from Bach's compositions and noting similar analytical skills required in both fields. It also references current research in computer-generated music and the potential for artificial intelligence to create new works in the style of composers like Bach.

Scientists do not yet fully understand abiogenesis, the origin of life, but research in the field is ongoing and philosophically or methodologically similar to other scientific research. The Miller-Urey experiment and the RNA world hypothesis are significant developments in understanding abiogenesis. Despite challenges, recent discoveries have advanced the field, such as the synthesis of RNA nucleotides and the potential formation of self-replicating RNA. The timing of abiogenesis and the role of the 'last universal common ancestor' (LUCA) are also areas of study. While there are still gaps and unanswered questions, the process of evolution after abiogenesis is well attested, and the lack of a full explanation for abiogenesis does not invalidate evolutionary theory. Creationist and intelligent design claims that unknowns in abiogenesis are a fatal flaw in evolutionary theory are considered invalid.

The upcoming Bitcoin halving, a scheduled event that reduces the block reward for miners by half, is expected to have a significant impact on network transaction fees and could drive consumer adoption of Bitcoin. The halving is part of a system designed to limit the supply of Bitcoin to 21 million. As the supply becomes more limited and demand increases, the price of Bitcoin is expected to rise. The halving may also lead to a shift towards second-layer networks like the Lightning Network, which offers lower transaction fees and faster processing, potentially making Bitcoin more accessible for everyday transactions and financially disenfranchised individuals.

The upcoming Bitcoin halving, a scheduled reduction in the block reward for miners, is expected to drive up transaction fees and highlight Bitcoin's limited supply. This event may accelerate consumer adoption of Bitcoin, particularly through the use of the Lightning Network, which offers lower transaction fees and faster processing times. The halving underscores Bitcoin's potential as a digital gold and a viable financial solution for the unbanked population, promoting broader use and integration into the global financial system.

The article explores the effectiveness of protests, highlighting recent examples where protests have led to political and social changes, such as in France, India, Hungary, and Panama. It discusses the skepticism towards protests, particularly in the UK, and provides evidence from academic research and historical instances to argue that protests can indeed make a difference. Key factors for effective protests include disruption, political support, and persistence. The article also emphasizes the empowering nature of protest participation and its long-term impact on individuals.

The article discusses the current global wave of protests calling for a ceasefire in Gaza, highlighting mass demonstrations, street blockades, and efforts to disrupt arms manufacturing. This is part of a decade-long trend of increasing protest activity.

The article examines the widely held belief that modern society is in decline, addressing concerns such as crime, environmental degradation, and moral decay. It presents data showing improvements in various areas like crime rates, life expectancy, and poverty reduction, while acknowledging ongoing challenges such as climate change, economic inequality, and social issues. The article argues that both science and religion can play roles in addressing these problems, emphasizing the importance of education and stable family structures.

The article discusses the reliability of geologic dating, particularly radiometric dating, emphasizing its strong scientific foundation and the consistency of results over decades. It addresses common criticisms from creationists, highlighting that anomalies are rare and often due to specific, explainable circumstances. The article cites multiple experts and studies to support the assertion that radiometric dating methods are robust and reliable, and it argues against the young-earth creationist perspective by presenting extensive evidence for an old Earth.

Fang Island's concert at Bowery Ballroom was a high-energy, triumphant event characterized by an abundance of guitars and an electrifying atmosphere. The band's new album, Major, was celebrated with an intense performance that had the audience air-guitaring along. The addition of Delicate Steve's guitarist added to the spectacle, culminating in a memorable night for attendees.

Tom Cruise stars in the upcoming sci-fi movie 'Oblivion,' directed by Joseph Kosinski, with a score by M83. The article humorously speculates on the movie's plot based on the first song from the soundtrack, describing scenes involving futuristic sports, drone missions, and a twist involving Morgan Freeman and Will Smith. The narrative is filled with playful conjecture and excitement for the film's release and its music.

Two Ukrainian women, Anna Bogachova and Irina Buevska-Cowell, performed a classical music concert in Bunbury to raise funds for Ukraine. The event, organized by Rev. Greg Ross at St Augustine Uniting Church, drew about 100 attendees. Both women, who have family still in Ukraine, expressed deep concern for their relatives amidst the ongoing conflict. The church and its congregation have been supportive of Ukraine since the Russian invasion in 2022.

Radiocarbon dating is a reliable method for dating artifacts up to roughly 50,000 years old, despite criticisms from creationists. The process, developed by Willard Libby, assumes a constant level of carbon-14 in the atmosphere, which has been shown to fluctuate, necessitating calibration. Techniques such as dendrochronology, uranium-thorium dating, optically stimulated luminescence, and varve sediment analysis are used for calibration. Studies by researchers, including a 2009 analysis of corals and a 2012 study by Christopher Ramsey's team, have established detailed calibration curves, making radiocarbon dating very reliable. Criticisms by creationists, such as those by Walt Brown, have been addressed and explained in scientific literature, such as Mark Isaak's book.

The article critically examines the claims made by creationists, particularly those associated with the Ark Encounter and Answers in Genesis, regarding the literal interpretation of Noah's Ark and the global flood. It highlights the scientific and theological challenges to these claims, including the inconsistency with geological records, the impracticality of the ark's logistics, and the lack of evidence for a global flood. The article argues that the Bible should not be read as a scientific textbook and that such interpretations detract from its spiritual message.

The article addresses the debate over 'missing links' between ancient primates and modern humans, arguing that the fossil record is rich with numerous species that illustrate the evolutionary lineage. It highlights the complexity of the human family tree, noting that many fossils have been discovered, representing various species, and discusses recent significant fossil finds such as Ardi, Denisovans, and Homo naledi. The article critiques creationist views that deny transitional fossils and emphasizes the importance of ongoing scientific research in understanding human evolution.

The article explores the historical relationship between science and religion, challenging the notion that they have always been in conflict. It highlights the religious roots of modern science, noting that many early scientists were religious. The article critiques Neil deGrasse Tyson's portrayal of science and religion as adversaries, providing historical examples where the two have coexisted and even supported each other. It discusses key figures like Copernicus, Galileo, and Darwin, and examines the evolution of the science-religion dynamic, particularly the rise of creationism in the 20th century and the impact of the New Atheists. The article concludes that the current polarization between science and religion is a relatively recent development and not historically typical.

Radiometric dating, a technique based on the rates of radioactive decay of various isotopes, is a cornerstone of modern geology and paleontology. It is used to date geological eras and specimens with high precision, thanks to quantum mechanics and advanced methods like the rubidium-strontium isochron method. Recent applications include dating dinosaur bones, confirming the meteorite impact theory for mass extinctions, and determining the timeline of Neanderthal existence in Europe. The reliability of these methods is well-established, making the young-earth worldview scientifically indefensible.

UK businesses, represented by industry body Make UK, have criticized the government for not having a clear industrial policy, especially in the context of green subsidies where the US and EU are taking significant steps. The US has introduced the Inflation Reduction Act and other initiatives totaling over $2 trillion to support domestic industries, while the EU has announced a €250 billion Green Deal Industrial Plan. The UK, however, has scrapped its industrial strategy and lacks a response to these international packages, with a significant investment shortfall in low carbon infrastructure. The Labour Party in the UK has proposed a £28 billion annual investment for a green transition, but there are concerns about its adequacy and potential conflict with WTO rules. The article suggests that the UK needs to establish its own Green New Deal to meet net zero commitments and compete globally.

Katie Schide, a Gardiner native, won the Ultra-Trail du Mont Blanc, a 172-kilometer race in the Alps, finishing as the top female competitor and 22nd overall. Schide, who also recently earned her Ph.D. in geology, completed the race in 23 hours, 15 minutes, and 12 seconds. The race, part of the Ultra-Trail World Tour, requires competitors to accumulate points through qualifying races. Schide's victory follows top-10 finishes in 2019 and 2021. She lives in a village near France's Mercantour National Park with her partner, Germian Grangier. The sport of ultra running has seen significant growth, with over 600,000 competitors in 2020.

A crisis of replicability in science has been highlighted by various studies across fields such as cancer research, economics, and psychology, with many unable to replicate the results of previous studies. In finance, the issue is exacerbated by backtest overfitting, where investment funds and strategies that perform well in backtests fail when applied in practice. A study by Kewei You, Chen Xue, and Lu Zhang analyzed 452 anomaly indicators in finance and found that most failed to replicate. The study suggests that capital markets are more efficient than previously recognized. The article also discusses the pressure to publish new results in academic finance, leading to a lack of rigorous verification of previous results. It calls for better education in modern statistics for finance researchers and practitioners to prevent statistical malpractices and improve replicability.

The article critiques the reliability of market forecasters, highlighting their poor track record in predicting stock market movements. It references analyses by Jeff Sommer, Paul Hickey, and Nir Kaissar, showing significant discrepancies between forecasts and actual market performance. The article argues that most market forecasts are no better than chance and suggests that individual investors would benefit more from following the investment strategies of experts like Jack Bogle, Warren Buffett, and David Booth, which emphasize low-cost index funds and long-term holding.

The United Nations Decade of Ocean Science for Sustainable Development offers a significant opportunity to improve the way the ocean is used. The deep-sea research community is outlined as having a crucial role in achieving these ambitious goals.

David Bailey recounts his interactions with the Kray twins, notorious gangsters from East End, London. He details a violent incident involving the Krays and his own father's past encounter with them. Bailey also describes his experience photographing the Krays' events and the fear and violence that surrounded their lives. Additionally, he reflects on his childhood during the Blitz in WWII, his family dynamics, and the tough environment of the East End.

The Mortgage Outlet offers low mortgage rates and a flat fee structure for home buyers and those refinancing in Lake Ronkonkoma, NY. The company promises no additional fees, a fast automated mortgage process, and the potential for a 30-day closing. With over 30 years of experience, The Mortgage Outlet emphasizes its commitment to serving the borrower's best interests.

The Mortgage Outlet offers low mortgage rates in Ronkonkoma, NY, with a flat fee structure that eliminates additional closing costs. The company highlights benefits such as cheaper mortgage rates, reduced closing costs, and a fast automated mortgage process. With over 30 years of experience, The Mortgage Outlet aims to provide innovative loan programs for home buyers and those looking to refinance.

Flat Rate Mortgage Broker, The Mortgage Outlet, offers low mortgage rates in Selden, NY, with a flat fee structure that eliminates additional closing costs. The program promises cheaper mortgage rates, reduced closing costs, and a fast automated mortgage process, aiming to benefit both home buyers and those refinancing. The company emphasizes its commitment to working in the borrower's best interest and providing a pleasant home buying or refinancing experience.

The Mortgage Outlet offers low mortgage rates in West Islip, NY, with a flat fee structure that eliminates additional costs such as processing and application fees. The company highlights benefits including cheaper mortgage rates, reduced closing costs, and a fast automated mortgage process. With over 30 years of experience, The Mortgage Outlet aims to provide innovative loan programs tailored to the needs of home buyers and those looking to refinance.

Flat Rate Mortgage Broker, The Mortgage Outlet, offers low mortgage rates in Great River, NY, with a flat fee structure that eliminates additional closing costs. The program promises cheaper mortgage rates, reduced closing costs, and a fast automated mortgage process, aiming to benefit both home buyers and those looking to refinance. The company emphasizes its commitment to working in the borrower's best interest and providing a pleasant experience tailored to individual needs.

The Mortgage Outlet introduces a flat rate mortgage program in Davis Park, NY, offering some of the lowest mortgage rates available. The program promises no additional fees, cheaper mortgage rates, and closing costs, along with a fast automated mortgage process. The company emphasizes its commitment to working in the best interest of borrowers, providing innovative loan programs for both home buyers and those looking to refinance.

Flat Rate Mortgage Broker, The Mortgage Outlet, offers low mortgage rates in Patchogue, NY, with a flat fee structure that eliminates additional closing costs. The program promises cheaper mortgage rates, reduced closing costs, and a fast automated mortgage process, aiming to benefit both home buyers and those refinancing their current homes. The company emphasizes its commitment to working in the borrower's best interest and providing a pleasant experience tailored to individual needs.

The Mortgage Outlet, a flat rate mortgage broker, is offering low mortgage rates in Bohemia, NY, with a flat fee structure that eliminates additional costs such as processing and application fees. This program aims to save borrowers thousands of dollars in closing costs and offers benefits like cheaper rates, lower closing costs, a fast automated mortgage process, and over 30 years of industry experience. The Mortgage Outlet emphasizes their commitment to the borrower's best interest and offers a 30-day closing option for those who qualify.

Flat Rate Mortgage Broker, The Mortgage Outlet, offers low mortgage rates in Bayport, NY, with a flat fee structure that eliminates additional closing costs. The program promises cheaper mortgage rates, reduced closing costs, and a fast automated mortgage process, aiming to benefit both home buyers and those refinancing. The company emphasizes its commitment to working in the borrower's best interest and providing a pleasant home acquisition or refinancing experience.

The Mortgage Outlet offers low mortgage rates in Sayville, NY, through a flat rate program that eliminates additional fees, aiming to save borrowers thousands in closing costs. The program is designed for both home buyers and those refinancing, emphasizing cheaper rates, lower closing costs, and a fast, automated mortgage process. The company highlights its 30 years of industry experience and commitment to working in the borrower's best interest.

Day-trading has surged in popularity during the COVID-19 pandemic, driven by factors such as bored millennial workers, zero-interest monetary policies, and government stimulus checks. Despite its rise, day-trading is criticized for being highly risky and often unprofitable, with studies showing that the majority of day-traders lose money. The article highlights severe financial losses and tragic consequences faced by amateur investors, and criticizes major brokerages and financial news media for promoting day-trading. The text strongly argues against the practice, emphasizing its dangers and the false sense of invincibility it creates among individual traders.

The article discusses the widespread impact of the Covid-19 pandemic and the concurrent rise in pseudoscientific beliefs and misinformation. It highlights the need for greater public scientific literacy to combat future pandemics effectively. The text criticizes various pseudoscientific claims, including astrological predictions and unproven medical treatments, and underscores the role of public figures in spreading misinformation. It calls for scientists to engage more with the public to improve scientific understanding and counteract misinformation.

DNA origami nanostructures functionalized with aptamers show promise as a vehicle for targeted antimicrobial delivery, addressing the urgent need for alternative strategies against antibiotic resistance. These nanostructures, which can carry and deliver the antimicrobial enzyme lysozyme to both Gram-positive and Gram-negative bacteria, demonstrate high specificity and efficiency. The study confirms the biocompatibility and stability of DNA origami, highlighting its potential for in vivo therapeutic applications. The research opens avenues for precise pathogen targeting and the delivery of combined antimicrobial compounds, potentially reducing the required dosage of antibiotics and enhancing their effectiveness.

The HamTown Smokers, led by Joshua and Heidi Shook, are making a name for themselves in the competitive barbecue circuit. Combining their scientific backgrounds with a passion for cooking, they have developed a unique approach to barbecue that emphasizes both skill and science. Their success in competitions, including becoming Grand Champions at the Brasstown Valley BBQ Throwdown, has qualified them for prestigious events like the American Royal Invitational. The Shooks' dedication to their craft, along with their innovative Hot’n’Fast technique, has brought them recognition and strengthened their family bonds.

Jim Simons, a former mathematician and cryptologist, revolutionized the financial markets by founding Renaissance Technologies and its flagship Medallion Fund, which achieved unprecedented success through advanced mathematical and computational techniques. Despite numerous personal and professional challenges, Simons' innovative approach to quantitative finance has left a lasting impact on the industry. His philanthropic efforts through the Simons Foundation and Math for America further highlight his contributions beyond finance. The narrative also touches on controversies, including tax strategies and political activism within his firm.

The article asserts that the scientific debate on climate change is conclusively settled, with overwhelming evidence of global warming and its anthropogenic causes. It references NASA data showing recent years as the warmest on record, and the Intergovernmental Panel on Climate Change (IPCC) reports on the dire consequences of a 1.5 C temperature rise. Common climate change myths are systematically debunked, and the article highlights a shift in opinion by former skeptic Richard Muller. Despite a strong scientific consensus, public skepticism persists, particularly in the United States. The article emphasizes the urgent need for action, as underscored by the impassioned speech of activist Greta Thunberg at the U.N. Climate Summit.

The article discusses the undeniable facts of climate change, highlighting the scientific consensus and contrasting it with public skepticism. It details the severe impacts already being felt, such as extreme weather events, rising sea levels, and biodiversity loss. Financial risks associated with climate change are analyzed, including the potential for stranded assets and physical destruction. Reports from Citigroup and the Network for Greening the Financial System are cited, emphasizing the need for integrating climate risks into financial strategies. Greta Thunberg's impassioned speech at the U.N. Climate Summit underscores the urgent call for action.

Marcos Lopez de Prado, named Quant of the Year for 2019 by the Journal of Portfolio Management, criticizes the current hype in machine learning within finance, noting the lack of track records among practitioners. He established True Positive Technologies to provide algorithms and expertise in this area. Lopez de Prado points out that many AI-based investment funds have underperformed and attributes this to fund managers not properly integrating theory with machine learning. He also differentiates machine learning from traditional regression and big data, emphasizing the need for sophisticated models to handle complex datasets. His vision is to make finance more scientific and less like a casino.

Big data and machine learning are revolutionizing finance by enabling organizations to spot trends and make predictions more accurately and quickly than traditional methods. Examples include hedge funds using satellite data to predict retail traffic and crop yields. The adoption of these technologies is growing, with significant increases in spending projected. Traditional investment managers face a choice: embrace these advanced technologies, switch to passive investing, or exit the industry. Successful quantitative hedge funds like Renaissance Technologies and Two Sigma continue to attract new funds and clients.

The article discusses the growing popularity of target-date funds in retirement planning, highlighting the significant adoption by Vanguard Group and projections by Paladin Research. It examines the implications of increasing life expectancy on investment strategies, questioning traditional equity/bond mix formulas. The text also explores advancements in longevity research by organizations like Calico and Unity, funded by notable figures such as Jeff Bezos. The potential financial consequences of longer lifespans are considered, suggesting a need for investors to reconsider their portfolios to ensure sustainability in retirement.

Global capitalism in 2019 is facing a crisis, with quantitative easing failing to resolve previous issues and creating conditions for a potentially greater future crisis. Negative interest rates and financial investors betting against long-term growth indicate systemic problems. The consequences of capitalism are felt through wage stagnation, insecure employment, and welfare state erosion in the Global North, and poverty, violence, and climate change in the Global South. The Critical Political Economy Research Network (CPERN) is meeting in Manchester to discuss these issues and explore alternatives to capitalism. The conference will feature discussions on digital capitalism, financialisation, austerity policies, and social movements resisting capitalist pressures.

Frank Fabozzi, a prominent figure in mathematical finance, has criticized the detachment of current academic economics and finance from real-world behavior, highlighting the failure of rational models and calculus-based theories to account for market complexities and crises. He advocates for a shift towards empirical science and the integration of machine learning models. The critique extends to university curricula, which Fabozzi believes should include both sophisticated mathematics and rigorous data science to prepare students for modern quantitative roles.

The study presents a method to improve fishing selectivity by targeting specific life stages of fish using life stage distribution modeling. It highlights the importance of understanding spatial distribution and ontogenetic shifts in fish populations to develop effective marine management strategies. The research focuses on whiting in the UK and Irish Sea, using generalized additive mixed effects models to predict the distribution of different life stages. The findings suggest that targeted fishing practices can help reduce bycatch and support the recovery of fish stocks, emphasizing the need for age-structured fishing regulations.

The article examines the scientific qualifications of Donald Trump's key cabinet and agency appointees, highlighting concerns about their views on climate change and scientific research. Rick Perry, Scott Pruitt, Ryan Zinke, and Elisabeth DeVos are criticized for their lack of scientific credentials and controversial stances on evolution, climate change, and environmental regulations. The article underscores the importance of scientific knowledge in government roles and calls for scientists to engage more with the public to counteract growing ambivalence and hostility towards science.

Over the past two decades, computational methods have significantly advanced research capabilities across various fields, but these advancements have also introduced challenges related to reproducibility. The article presents Reproducibility Enhancement Principles (REP) to address transparency issues in computational methods. These principles build on existing guidelines and emerged from discussions among diverse stakeholders, including funding agencies, publishers, industry participants, and researchers. The recommendations aim to improve the disclosure of computational methods to mitigate irreproducibility in scholarly literature.

Driverless cars, while potentially perceived as dull, are poised to revolutionize urban mobility. Reports from Gowling WLG and UK Autodrive highlight the need for clear regulations and safety protocols, while the Rocky Mountain Institute predicts a significant shift from car ownership to automated mobility services. This shift could lead to substantial economic savings and a redesign of urban spaces, prioritizing people over cars. Key figures in the discussion include Stuart Young from Gowling WLG and Tim Armitage from Arup, emphasizing the balance of safety, commerce, and legality in the development of autonomous vehicles.

Dave Bailey discusses a common issue among founders who have lost sight of the specific problem their business was created to solve. He notes that it's not uncommon for founders to temporarily forget the core purpose of their startup.

The article argues for the importance of integrating humanities with STEM education, highlighting the economic and societal benefits of a well-rounded education. It criticizes politicians who advocate for prioritizing STEM fields over humanities and emphasizes the need for scientists to communicate better with the public. The text underscores the role of humanities in fostering critical thinking, creativity, and effective communication, which are essential in addressing modern societal challenges.

The article explores the potential of ketone bodies as an ergogenic aid for athletes, particularly in endurance sports. It discusses the mechanisms by which ketone bodies can serve as an alternative fuel source, their impact on carbohydrate and fat metabolism, and the practical considerations of using ketone body supplements. While ketone bodies may improve metabolic efficiency and spare glycogen stores, their effectiveness in enhancing high-intensity exercise performance remains uncertain. The article calls for further research to validate the benefits and address the practical challenges of ketone supplementation in elite sports.

West Virginia's worst flooding in over a century has resulted in at least 24 deaths and significant devastation, prompting federal assistance for the most affected counties. President Obama declared a major disaster and ordered aid for Kanawha, Greenbrier, and Nicholas counties. The state has declared a state of emergency in 44 of 55 counties, with extensive rescue efforts underway. The Greenbrier resort and the Greenbrier Classic golf tournament have been significantly impacted, leading to closures and cancellations.

Cancer cells exhibit significant phenotypic diversity, making them suitable for phenotypic screening. Advances in genetics and genomics have enhanced our understanding of the relationship between genotype and phenotype, aiding drug discovery in oncology. Glioblastoma multiforme (GBM), a rare and complex cancer, lacks effective long-term therapies. Recent research offers hope for new phenotypic screening methods to improve diagnosis and treatment. Drug repurposing and patient-centric preclinical diagnostics are promising approaches. New surgical methods and cell-based systems are being developed to facilitate GBM drug discovery. Targeting brain tumor stem cells and specific molecular targets like STAT3, PLK-1, and CDK genes shows potential. A multipronged approach combining clinical excellence, cutting-edge cell biology, and patient-centric diagnostics is essential for advancing GBM drug discovery.

The article explores the commonalities between mathematics and music, noting that many mathematicians have an interest in music, with some being accomplished musicians. It discusses the mathematical relationships in music, the structural similarities between musical syntax and mathematical thinking, and the use of computers in music composition. While it acknowledges the difficulty in scientifically proving a link between mathematical and musical talent, it suggests a deep connection between the two disciplines.

Humanity's interest in space exploration is experiencing a resurgence, driven by successful private firms like SpaceX and Blue Origin, and ambitious projects such as Yuri Milner's Breakthrough Starshot. Renewed interest in Mars colonization is evident with plans from Mars Society, Mars One, and Elon Musk's Mars Colonial Transporter. Advanced propulsion technologies are being explored by NASA to facilitate deeper space travel. These developments challenge Fermi's paradox and suggest that humanity may soon become a multi-planet and eventually a multi-solar-system species.

Scientific frauds occasionally shake the scientific community, undermining public trust. High-profile cases have involved individuals like Derek Stapel, but these are exceptions. The article discusses the public's skepticism towards scientific consensus on evolution and climate change, despite overwhelming peer-reviewed evidence. It also addresses the improbability of large-scale scientific conspiracies, citing a study by David Robert Grimes that used probabilistic models to show such conspiracies would likely be exposed within a few years. The article concludes that major scientific facts are not part of a conspiracy and that scientific findings, though sometimes inconvenient, must be accepted as reliable facts to maintain a rational worldview.

The article discusses the ongoing debate in the field of physics between proponents of string theory and the multiverse, and their critics who argue that these theories lack empirical testability and falsifiability. It highlights the discovery of the Higgs boson and potential new particles, while also addressing the criticisms from figures like Peter Woit, George Ellis, and Joseph Silk. The article emphasizes the importance of empirical testing in scientific research and warns against the dangers of diluting these standards, citing examples from climate change denial to pseudoscientific health claims.

Four men are being held by Minneapolis police in connection with the shooting of five protesters demonstrating against the fatal police shooting of Jamar Clark, an unarmed black man. The suspects, three white and one Asian, are under investigation by the Hennepin County Attorney's office. The incident has intensified ongoing protests and debates over police use of lethal force against black individuals in the United States. The Minneapolis Urban League and Clark's family have called for an end to demonstrations to restore neighborhood order. Authorities are reviewing various video sources to investigate the shooting, while activists demand the release of related footage.

Andrea Rossi, an Italian-American inventor, discusses his work in the field of low energy nuclear reaction (LENR) energy, highlighting his motivation to provide low-cost, environmentally friendly energy. Rossi explains the scientific principles behind his E-Cat system, which aims to produce energy through nuclear reactions without emitting harmful radiation. He addresses skepticism by emphasizing the importance of producing commercial products to prove his technology's efficacy. Rossi also mentions ongoing research collaborations and the challenges of achieving reliable, stable energy production. He expresses optimism about the future of LENR and its potential applications in various industries.

Volkswagen's 'dieselgate' scandal may accelerate the shift towards electric vehicles (EVs) as cities and governments consider restricting diesel use due to pollution. European manufacturers' focus on diesel may have hindered the transition to EVs, unlike Japanese and American firms that have invested in hybrids and electrics. Tesla and other companies are seen as potential beneficiaries, with Tesla's battery innovations and the development of autonomous cars by Google and others poised to transform urban mobility.

Kim Davis, a county clerk in Kentucky, was taken into custody for refusing to issue marriage licenses to same-sex couples on religious grounds, defying a U.S. federal judge's order. District Court Judge David Bunning emphasized the seriousness of the court's decision. The case highlights ongoing legal and civil rights issues surrounding same-sex marriage in the United States.

The article discusses the urgent need to reduce fossil fuel consumption due to climate change risks, highlighting advancements in solar and wind energy. It explores the potential of fusion energy, with notable progress reported by Lockheed Martin, Tri Alpha Energy, and Energy/Matter Conversion Corporation. The article also covers Low Energy Nuclear Reaction (LENR) projects, including Brillouin Energy Corp.'s controlled electron capture reaction and Andrea Rossi's controversial tabletop reactor. Despite skepticism, Rossi's work has shown promising results, with independent replications by other researchers. The implications of these developments remain uncertain, pending further technical details and validation.

A worker died and another was seriously injured after falling while performing roofing work on the U.S. Bank Stadium in downtown Minneapolis, which is being built for the Minnesota Vikings. The incident led to the halting of all construction activities at the site. The workers received immediate medical attention and were taken to a hospital. The stadium, which is 70 percent complete, is expected to be finished by July 2016. Mortenson Construction, the contractor, reported the incident.

Crime rates in the U.S. and other first-world nations have significantly declined over the past few decades, contrary to public perception. The article examines the relationship between gun control laws and crime rates, finding no evidence that stricter gun controls lead to higher crime rates. It highlights that right-to-carry laws may be associated with increased violent crime. The article also discusses the political use of crime statistics and the potential for changes in public policy based on factual data.

A U.S. appeals court permanently blocked a North Dakota law banning most abortions once a fetal heartbeat is detected, upholding a previous decision that states cannot prohibit pre-viability abortions. The court acknowledged potential changes in the concept of viability due to medical advancements. The law, challenged by the Red River Women's Clinic and represented by the Center for Reproductive Rights, was deemed unconstitutional. The decision reaffirms protections for women's rights to safely and legally end pregnancies.

On April 21, 2015, the U.S. Department of Justice announced criminal charges against British day-trader Navinder Singh Sarao for his alleged role in causing the 2010 'Flash Crash'. The article critiques the technical inadequacies of market regulatory agencies, highlighting the initial blame on a mutual fund's large sell order and later recognition of order imbalance as the cause. It discusses the role of High Frequency Trading and spoofing in modern markets, the failure of regulators to promptly identify the real causes of the crash, and the protective nature of Section 8 of the Commodity Exchange Act towards spoofers. The article suggests that the current market structure is prone to accidents and that regulators lack the data science expertise needed to prevent such events.

The article explores the enduring mystery of Fermi's Paradox, questioning why extraterrestrial intelligence remains undetected despite extensive searches. It reviews various proposed solutions, including sociological and technological explanations, and discusses the concept of a 'great filter' that might prevent civilizations from advancing to a detectable stage. The possibility of post-biological intelligences is also considered, suggesting that advanced extraterrestrial societies may exist in forms beyond human comprehension. The article concludes with the perspective that humanity might be alone in the observable universe, though the discovery of extraterrestrial intelligence would be a thrilling revelation.

Fermi's Paradox, posed by Nobel physicist Enrico Fermi 65 years ago, questions why we have not detected any extraterrestrial civilizations despite the high probability of their existence. Various hypotheses and counterarguments are discussed, including the possibility of civilizations being too far away, losing interest in communication, or self-destructing. The concept of a 'great filter' is introduced, suggesting a major barrier to advanced civilizations. The article emphasizes the ongoing mystery and the importance of continued scientific inquiry.

2014 was a challenging year for market forecasters and hedge funds, with many failing to outperform basic index-based strategies. Hedge funds on average returned only 3.9%, while major indexes like the S&P 500 and Nasdaq saw much higher gains. Warren Buffett's bet that an S&P 500 index fund would outperform a hedge fund over ten years seems likely to succeed. The article also discusses the inevitability of market crashes and the difficulty of making accurate market predictions due to the complex nature of financial markets.

The article discusses the potential of Low Energy Nuclear Reactions (LENR) as an alternative energy source to fossil fuels, highlighting the urgency due to climate change impacts reported by the Intergovernmental Panel on Climate Change. It reviews the history of LENR, including the discredited cold fusion claims by Martin Fleischmann and Stanley Pons, and the skepticism surrounding current claims by entities like Brillouin Energy Corp. and Andrea Rossi's E-Cat. The article also mentions interest from figures like Bill Gates and Steven Chu, and involvement from companies such as Mitsubishi and Toyota. It emphasizes the need for reproducibility and peer review in scientific research, especially for extraordinary claims like those made by LENR proponents.

The article critiques the over-precision of data presented in various reports across different fields, including oil price projections by OPEC, employment figures by the U.S. Bureau of Labor Statistics, and budget figures by the European Commission. It argues that presenting data with more digits of accuracy than justified can mislead readers and undermine the rationale of scientific estimation. The article calls for authors and producers of such data to present figures to levels of accuracy that can be rigorously justified to avoid engaging in pseudoscience.

The UN's IPCC report warns of severe climate impacts from greenhouse-gas emissions, advocating for green energy solutions. Conservation and solar power are discussed as partial solutions, but the need for a reliable, clean energy source remains. Nuclear fusion, particularly recent claims by Lockheed Martin and Andrea Rossi's E-Cat, is presented as a potential solution, though both are met with skepticism due to a lack of details and theoretical support. The article emphasizes the importance of peer review and independent verification before accepting such revolutionary claims.

The new music video for 'Killer Snake' by Detroit garage rock band Mexican Knives demonstrates that payphones and cell phones can coexist peacefully. Despite Detroit's financial struggles, the city continues to produce high-quality rock 'n' roll. Mexican Knives' new album is set to release this fall, followed by an East Coast/Midwest tour.

Crystal Fighters released a new video for their song “You & I,” which is described as 'sadorable,' a blend of 'sad' and 'adorable.' The video features a bird and a tree, named Kevin and Jennifer for the article's purposes, who are best friends with a 'will-they-won't-they' dynamic. The narrative turns dramatic, likened to a 17th century Italian opera. The article also mentions Earth Day and the importance of thinking about the planet. Crystal Fighters' album 'Cave Rave' is set to release on May 28th, and the band will tour North America in June.

Smash Mouth is celebrated for their extensive presence in movie soundtracks, with notable mentions of their songs in films like 'Shrek,' 'Mystery Men,' and 'Rat Race.' The band's song 'All Star' is highlighted for its frequent appearances in movies, and the article humorously explores the band's dominance in the film industry. The author, David Bailey, uses a mix of personal anecdotes and investigative journalism to underscore Smash Mouth's impact on pop culture.

Halasan Bazar, a Copenhagen-based experimental psych-pop group, has released a new track titled "Sometimes Happy, Sometimes Sad," which is part of their upcoming album 'Space Junk.' The article humorously discusses the real issue of space debris, also known as space junk, highlighting its potential to form a 'Crap Shroud' that could have serious consequences for Earth. The piece suggests there is currently no solution to the problem of space junk, and ends with a whimsical suggestion to enjoy the music while contemplating the debris orbiting our planet.

Charli XCX's new video for 'Cloud Aura' featuring Brooke Candy is a stylish, black-and-white montage filled with various crying scenes from famous personalities and characters. The video is described as a badass breakup song with a defiant attitude.

The article enthusiastically promotes Rudimental's song 'Not Givin’ In,' highlighting its soulful and energetic qualities, including its saxophone and 'wub wub' elements. The music video serves as a cautionary tale about breakdancing in the slums. The tone is playful and filled with puns.

The article humorously explores the resurgence of obsolete music-listening devices like vinyl records, cassette tapes, and other archaic musical gadgets. It reflects on the nostalgia and perceived coolness associated with these devices, contrasting them with modern technology. The piece lists various outdated devices, such as the Talkboy Tape Recorder and MiniDisc, and discusses their unique features and cultural impact.

Austin garage rock band A Giant Dog discusses their new EP and upcoming album, sharing insights on their creative process, inspirations, and experiences with recording. They also talk about their relationship with Spotify, including how they benefit from the platform. The interview touches on various quirky topics, reflecting the band's unique personality and approach to music.

Former U.S. Democratic Senator George McGovern, known for his 1972 presidential run against Richard Nixon and his humanitarian efforts, is near death in a South Dakota hospice. McGovern, 90, has been unresponsive and surrounded by family. His legacy includes significant contributions to social issues like world hunger and AIDS. McGovern's career spanned roles in the U.S. House of Representatives, the Senate, and as the first director of the Food for Peace Program. He continued to influence public policy and debate through his writings and appearances. In 2000, he was awarded the Presidential Medal of Freedom by President Bill Clinton.

The author recounts a memorable concert experience at Webster Hall featuring Twin Shadow and Niki and the Dove. Choosing to disconnect from social media, the author immerses in the live performance, highlighting the energetic atmosphere and personal interactions. Twin Shadow, led by George Lewis Jr., delivered a captivating show with visual effects and audience engagement. The night concluded with a nostalgic cab ride, leaving a lasting impression.

A basket is a set of instruments held together to achieve a goal like hedging or trading that individual constituents cannot achieve. Balanced baskets, which spread risk across constituents without changing the basis, are preferred by practitioners. The article reviews three methodologies for determining balanced baskets, analyzes their features, and provides Python code for their calculation. It also introduces a new method called covariance clustering to reduce the dimension of a covariance matrix, addressing numerical ill-conditioning without changing the basis.

Icona Pop, the Swedish pop duo, performed on the Soho House Rooftop, delivering an energetic set that included their hits 'I Love It' and 'Manners,' as well as their new track 'Ready for the Weekend.' The performance was part of a hectic schedule that included multiple gigs in one day during Fashion Week. The duo discussed their inspiration from the London dance music scene and their experiences performing at various events. The article captures the lively atmosphere of the performance and the duo's enthusiasm for their music.

Noisey, a section of Vice, humorously imagines a fictional video game called 'Estrodome' where female rock stars battle each other with special combo moves. The article describes various musicians, such as Krauss from Sleigh Bells, Mosshart from The Kills and The Dead Weather, and Clark, also known as St. Vincent, among others, in a satirical tone, attributing fictional moves to them and picking winners in hypothetical matchups.

Crystal Fighters' new EP, 'At Home,' offers a collection of remixed chill grooves designed to help listeners relax and unwind. The article humorously describes the EP as a remedy against the 'tyranny and oppression' of crystalline overlords. The band is also set to release a full-length album, 'Star of Love,' on September 25th, which promises more exciting remixes.

The article humorously explores the history and impact of instructional dance songs, highlighting how these songs provide specific dance instructions to help people who feel they can't dance. It discusses various iconic dance songs such as 'The Hokey-Pokey,' 'Let's Twist Again,' 'The Time Warp,' 'Cha Cha Slide,' 'Lean Back,' 'Cupid Shuffle,' 'Teach Me How To Dougie,' and 'Lemme Smang It,' noting their unique contributions to dance culture and their role in making dancing more accessible.

The 4Knots Music Festival at South Street Seaport experienced a significant fire incident, which was reported live by David C. Bailey, who was not initially supposed to be in the VIP area. The festival featured performances by Nick Waterhouse, Bleached, Hospitality, and the Crocodiles. Despite the fire, no injuries were reported, and the cause of the fire remains unknown. The FDNY responded to the incident, and there were humorous mentions of Billy Joel being questioned by the arson lab.

A Private Investigative Journalist recounts a story involving a personal investigation into the song 'How Deep Is Your Love?' by The Rapture, drawing connections to Dru Hill's hit from 1998 and Sisqo's 'The Thong Song.' The article narrates an adventure involving illegal activities to uncover the truth, which is humorously suggested to be that The Rapture is Dru Hill in disguise. The evidence was lost in a fire at a mannequin factory, and the story is presented with a mix of facts and narrative storytelling.

The author recounts attending a Japandroids concert dressed as Data, an android from Star Trek, to learn about humanity and for humorous effect. Despite the odd looks and avoidance from subway passengers and concertgoers in Williamsburg, Brooklyn, the author stays in character, observing the event stoically. Eventually, the author joins the mosh pit, embracing the human experience of live music and the emotions it elicits, particularly rage. The night ends with the author reflecting on the acceptance of artificial lifeforms in society and the normalcy of oddities on the Bedford L Train platform.

The article humorously discusses the trend of naming bands with the template 'The [Adjective] [Noun]s,' highlighting various popular band names and their unique characteristics. It emphasizes the importance of choosing a current and reflective name for a band to ensure it resonates with the times and avoids outdated connotations.

The article humorously suggests various music tracks to accompany different sports activities, emphasizing the importance of a good soundtrack to enhance the experience. It recommends metal music for badminton, playful tunes for softball, ethereal rock for basketball, retro vibes for biking, unconventional choices for skateboarding, and a mix of punk and cinematic scores for jogging. The tone is light-hearted and opinionated, with a focus on personal enjoyment and creativity in sports.