The study explores how mitochondrial modulation contributes to age-associated fluconazole tolerance in Cryptococcus neoformans, highlighting the mechanisms driving resilience in aging.

The 2024 Women's Brasileirão kicks off with matches featuring top Brazilian athletes. The tournament, gaining more visibility each year, starts on March 15 with three games, including a match between Ferroviária and Botafogo. Key players from various teams are highlighted, and the competition will follow a four-phase format. TV Brasil and Rede Globo will broadcast the matches, with SporTV focusing on the qualification phase.

137 men were arrested, including three with preventive detention warrants, and three minors were apprehended in an operation targeting crimes against women in Rio de Janeiro. The operation, involving the State Civil Police and Military Police, aims to capture perpetrators and includes preventive activities like lectures and social actions. Nearly 2,000 victims have been assisted, with an increase in protective measure requests and crime reports. The operation will conclude on March 29, covering all 92 municipalities in the state.

A bus robbery in Rio de Janeiro resulted in the death of Carlos José de Sales Silva, a hardworking man who was returning from work. The incident occurred when a robber announced the heist on the 404 bus line, leading to a passenger's reaction and subsequent gunfire. Carlos was fatally shot in the head, while two other passengers were injured. His sister, Aparecida Salles, expressed deep sorrow and highlighted the daily fears faced by workers using public transport.

Cadu Batuqueiro, a young boy who went viral for his emotional reaction to Mocidade Independente de Padre Miguel's samba performance, has been invited to parade with the children's section of the school. The article highlights the deep-rooted family tradition of carnival, with Cadu's passion influenced by his grandmother Alcina and supported by his mother Sílvia and sister Mariana Loureiro. Cadu's emotional connection to the samba school and his admiration for singer Zé Paulo are emphasized, showcasing the generational love for samba within his family.

Scammers are posing as health surveillance inspectors in Rio de Janeiro, exploiting the period when the population needs to regularize the Annual Licensing Fee. The president of IVISA-Rio, Aline Borges, clarifies that legitimate inspectors are always identified and never request money or contact establishments in advance. IVISA-Rio has used social media to inform the public that they do not contact establishments to notify them of inspections or request confidential information.

Heavy rains in the Metropolitan Region of Rio de Janeiro have caused severe flooding in the neighborhood of Amapá, Duque de Caxias, leaving streets submerged and residents seeking higher ground. The flooding was exacerbated by water from the Rio Iguaçu overflowing gates, according to the Instituto Estadual do Ambiente (Inea). The situation has led to the deaths of 12 people and the disappearance of two others. The governor in exercise, Thiago Pampolha, noted that only 2 out of 5 drainage pumps are operational, and the area suffers from irregular occupation. Emergency measures have been enacted, and rescue operations are ongoing.

Beatriz, a passenger, recounted a harrowing experience during a police operation in Vigário Geral, Rio de Janeiro, where a shootout occurred. The bus driver, known as Batata, was praised for his quick thinking in driving through the danger. The operation aimed to capture Álvaro Malaquias Santa Rosa, a local drug lord. The shootout resulted in the deaths of a police officer and three suspects, with additional injuries reported. The incident disrupted train services and highlighted the ongoing violence in the area.

The Military Police arrested Lucas da Silva Portela Xavier, a suspect in the murder of councilor Aldecyr Maldonado, known as Cici Maldonado, who was shot dead in front of his home in São Gonçalo. The arrest was made by agents of the 7th BPM in a joint operation with the Homicide Division of Niterói, São Gonçalo, and Itaboraí. The suspect had fled to the Salgueiro Complex after the crime and was apprehended following anonymous tips. The Civil Police continue to search for other possible suspects involved in the crime.

A family discovered a rat in a children's hospital room in Botafogo, Rio de Janeiro, where their daughter was recovering from surgery. The incident caused alarm among patients and staff, and the family criticized the hospital's hygiene standards. The hospital stated that they transferred the patient to another room and regularly conduct pest control measures. The family remained dissatisfied, noting further issues in the new room.

Black women were the majority of femicide victims in Rio de Janeiro last year, according to the ISP's Dossier on Women, which also reports that 125,000 women were victims of violence, averaging 14 per hour. Psychological violence was the most common, with 43,594 cases. The report was released on Tuesday. A woman, who remained anonymous, shared her experience of being assaulted four years ago by her ex-boyfriend, who was imprisoned for 18 days and now wears an electronic ankle monitor. She remarried and had another child but separated after suffering psychological violence. Marcela Ortiz highlighted the challenges in reporting violence, often perpetrated by intimate partners or family members, and the societal structural sexism that blames victims.

In Rio de Janeiro, 125,000 women were victims of violence last year, with most incidents occurring at home. Psychological violence was often perpetrated by partners or ex-partners, driven by jealousy, distrust, relationship endings, and possessiveness. Marcela Ortiz, ISP's director-president, emphasized the role of structural machismo and the need for support for women unable to report abuse. Christine, a victim of psychological violence, founded the support network Ser Ela after overcoming her ordeal. Her ex-husband was sentenced to a year in prison, later converted to participation in a reflective group for violent men, though he has not complied with the terms.

A pet birthday party with a Halloween theme was held for Auri, a dog adopted by Claudia Machado Ribeiro, in Rio de Janeiro. The event featured a complete buffet for the canine guests and professional photography. The pet industry in Brazil is expanding, with the pet food segment expected to generate R$ 36 billion in 2023, reflecting a 10.6% growth from the previous year. The article also highlights a pet buffet created by Lilian Ribeiro and a dog hotel with spa services.

A woman reported being raped by an app driver after being unable to pay R$ 55 for a ride. The incident occurred on August 21 in Rio de Janeiro. The driver allegedly refused to accept credit payment and demanded cash or Pix. When the woman couldn't arrange the payment, the driver assaulted her. She criticized the app company, inDrive, for not providing support or attention to her complaint.

The police are investigating a scam involving pet cremation services where criminals forge certificates and dispose of animal bodies improperly, often in rivers or trash bins. Pet owners, like Roberto Pita, have discovered that the cremation certificates they received were fake. Authorities, including the OAB-RJ and CRMV, emphasize the importance of verifying the legitimacy of these services to prevent further distress for pet owners. The investigation aims to ensure that those responsible are held accountable and to prevent environmental crimes.

Dogs in the Vila do Pan condominium in Barra da Tijuca have been falling ill and dying after walking in common areas, with symptoms suggesting poisoning. At least three dogs have died, and residents suspect the cause is related to products used in the gardens or pest control. The police and environmental protection agencies are investigating, and the condominium could face legal consequences for animal cruelty. The pest control company denies responsibility, stating their products are safe and used according to regulations.

The article, authored by Natalia Abreu de Oliveira, Sheila Marques Fernandes Couto, Fernanda Teixeira Borges, Maria de Fátima Fernandes Vattimo, and Cassiane Dezoti da Fonseca, discusses the effects of L-Carnitine on contrast-induced nephropathy in diabetic rats. The study has been withdrawn.

The study investigates the effects of L-Carnitine on contrast-induced nephropathy in diabetic rats, providing insights into potential therapeutic benefits and mechanisms.

The Vivo Rio Pro, a stage of the world surfing championship, began on June 23, 2023, at Praia de Itaúna in Saquarema, Brazil. Brazilian surfers Filipe Toledo, Ítalo Ferreira, João Chianca, and Yago Dora advanced to the next stage, with Ferreira achieving the best score of the day. The event also features female surfers, with Silvana Lima and Tatiana Weston-Webb currently in the repechage. The competition will determine the five men and five women who will compete for world titles and Olympic spots for Paris 2024. The event is broadcast on Sportv and the WSL's YouTube channel.

Gabriel Medina has advanced to the fifth round of the ISA World Surfing Games 2023, held in El Salvador, maintaining his status as a favorite alongside Japan's Kanoa Igarashi. Other notable Brazilian surfers, Filipe Toledo and João Chianca, continue in the repechage rounds. The event does not offer direct Olympic qualification for American surfers, who will compete for spots at the 2023 Pan American Games in Santiago, Chile. The ISA Games will allocate eight Olympic spots to the top athletes from Africa, Asia, Europe, and Oceania. The competition can be viewed live on Olympics.com, with the next rounds scheduled for June 5.

Brazil concluded the 2023 Pan American Mountain Bike Championship in Congonhas with a total of 41 medals, leading the nations' ranking. The USA and Mexico secured Olympic spots for the 2024 Paris Games. The Mexican team, lacking a dedicated cycling federation, performed notably, securing two male and two female spots for the Santiago 2023 Pan American Games and one male spot for the Olympics. The event was organized by the Brazilian Cycling Confederation with oversight from the Pan American Cycling Confederation and the International Cycling Union.

The 'Era do Diálogo' event, organized by Consumidor Moderno, focuses on harmonizing consumer relations in Brazil, addressing the theme 'Effectiveness in the New Data Age'. Roberto Meir, CEO of Grupo Padrão, highlighted the challenges of excessive judicialization in Brazil, which is a world leader in this area, and its impact on consumers. The event also discussed the need for trust between parties to avoid treating each case as a legal dispute. Vitor Hugo do Amaral Ferreira from Senacon emphasized the enduring importance of consumer rights such as safety, information, freedom of choice, and participation, with a current focus on data protection and combating misinformation. The event, now in its 11th year, is a key forum for discussing consumer relations evolution, gathering public authorities, consumer defense system professionals, regulatory agencies, consumer law experts, and executives from major companies.

On the third day of the Pan-American Mountain Bike Championship, Brazil's Raiza Goulão secured second place in the Short Track event, while José Gabriel finished fourth in the men's category. The women's race saw a strategic play by the U.S. team, but Goulão and Karen Olimpio kept Brazil in contention. In the men's race, José Gerardo Arevalo from Mexico took the lead in the final laps to win. The event is organized by the Confederação Brasileira de Ciclismo with international oversight and local sponsorship.

National Secretary of Consumer, Wadih Damous, Anatel President Carlos Manuel Baigorri, and DPDC Director Ricardo Blattes discussed measures against the spread of violent content on social media, particularly on Telegram. Telegram faces an administrative process by Senacon for circulating illegal content, including threats and hate speech. The platform was suspended for not providing data on neo-Nazi groups to the Federal Police. The Justice Federal of Espírito Santo increased the daily fine for non-compliance from BRL 100,000 to BRL 1 million. This is the second suspension of Telegram services in Brazil in just over a year.

The 2023 Pan-American Mountain Bike Championship kicked off in Congonhas, Brazil, with the host nation securing a silver medal in the Team Relay event. Canada won gold, and Mexico took bronze. The Brazilian team, consisting of Gustavo Xavier, Otavio Queiroz, Giuliana Morgen, Gabriela Ferolla, Raiza Goulão, and José Gabriel, performed admirably, with Gabriel's fast lap securing second place. The event serves as a qualifier for the Santiago 2023 Pan-American Games and the Paris 2024 Olympics. The Confederação Brasileira de Ciclismo is broadcasting the event live on YouTube.

Gerdau Minas defeated Osasco São Cristóvão Saúde with a score of 3-0 in the Superliga Women's Volleyball semifinal, qualifying for the final. The match took place at Arena Unibh, and Minas now awaits the winner of the semifinal between Praia Clube and Sesc Flamengo. Thaísa and Pri Daroit, key players for Minas, emphasized the importance of tactical discipline and composure. Coach Nicola Negro highlighted the team's serve, block, and defense as decisive factors. The final is scheduled for May 7 in Uberlândia, MG.

On Saturday night in Japeri, Baixada Fluminense, Lusmar, a retired sub-lieutenant, attempted to kill his wife during a dispute after a party. Witnesses intervened and called the police. Lusmar threatened to shoot anyone who approached and subsequently fired at the police, who returned fire, injuring him. He was taken to a local clinic and later transferred to a hospital in Nova Iguaçu. No police officers were injured.

A retired sub-lieutenant, Lusmar Sofiste, attempted to kill his wife during a dispute after a party in Japeri, Rio de Janeiro. Witnesses called the police, and upon their arrival, Sofiste shot at the officers, who returned fire, injuring him. He was taken to a local clinic and later transferred to the Hospital Geral de Nova Iguaçu in critical condition. The Military Police confirmed the incident and the seizure of Sofiste's weapon.

As Easter approaches, there is a noticeable increase in demand for homemade products, driven by the significant price hike in chocolate and milk. Nubimetrics reports a 70% increase in searches for chocolate bars, molds, and fillings, indicating a trend towards DIY Easter treats. Hershey's is diversifying its product range, introducing limited edition flavors like Merengue de Morango and reinforcing its Hershey’s Coffee Creations, Special Dark, Ovomaltine, and Cookie’s N Creme lines. The pet market is also expanding, with a surge in searches for pet-friendly Easter eggs, as chocolate is toxic to animals. Mi Dolce Pet Chef, led by Cristiane RWanderley, offers a range of natural and safe Easter treats for pets, reflecting the growing inclusion of pets in family celebrations.

Thiago, a cameraman and photographer, was shot dead by Marcelo de Lima, a penal officer, following a dispute over pizza at a bar near Maracanã. Friends and colleagues mourn his loss, describing him as a person who made a significant impact on those around him. Marcelo, who allegedly fired nine shots, has been detained, with the court rejecting his self-defense claim. The incident has led to widespread condemnation and an administrative investigation by the Secretaria de Administração Penitenciária.

The Brazilian delegation secured two out of four possible medals at the Zagreb 2023 World Boccia Intercontinental Challenger in Croatia. Evani Calado won a silver medal in the BC3 class after a strong semifinal against fellow Brazilian Evelyn de Oliveira but lost to Poland's Małgorzata Perlińska in the final. Evelyn de Oliveira won the bronze medal after a tough match against Britain's Sally Kidson. Both athletes expressed satisfaction with their performances and are focused on future competitions, including the goal of qualifying for Paris 2024.

Febraban's Ombudsman Report indicates a 10% decrease in customer service requests and complaints in 2022 compared to 2021, with a total drop from 190 million to 171 million. Over the last four years, there has been a 31.5% reduction from 250 million requests in 2019. The decline is attributed to consumer behavior shifts towards digital channels and banks' investments in technology, which totaled over R$ 35.5 billion in 2022, an 18% increase from the previous year. The report also highlights the effectiveness of customer service channels, the role of Febraban's Committee on Ombudsman, Customer Relations, and Service Channels, and the high resolution rate of internal bank channels, with a 96% Ombudsman Resolution Index and two-thirds of demands resolved within a week. The report also details demands by product, with Credit Card/Multiple accounting for the highest volume at 22.5%.

Easter 2023 is expected to be more expensive for consumers in Brazil due to a significant rise in chocolate prices, driven by increased costs of ingredients like milk, sugar, and cocoa. Factors such as general inflation, the Ukraine war's impact on fertilizer prices, and climate events like La Niña have contributed to this price surge. Consumers are advised to consider less premium options or make their own chocolates. Despite the price hikes, chocolate sales are projected to increase, with brands introducing new products to attract buyers. The Associação Brasileira da Indústria de Chocolates, Amendoim e Balas (Abicab) reports a 13% growth in Easter egg sales in 2022 and anticipates further growth in 2023.

Minas defeated São Paulo 87-76 in a National Basketball League (NBB) game held at Arena UniBH in Belo Horizonte. This victory brings Minas closer to São Paulo in the league standings, with Minas now having 18 wins and seven losses in 25 games. Wesley Castro was a standout player, scoring 12 points and grabbing three rebounds. The game was part of the lead-up to the NBB All-Star Game, celebrating the league's 15th anniversary, which will also be held in Belo Horizonte.

Silvana Lima and Luan Wood emerged victorious at the Layback Pro QS 3000 in Florianópolis, securing 3000 points each in the South American ranking. Silvana Lima's win also earned her a spot in the Challenger Series 2023. The event marked the 50th Qualifying Series stage in Santa Catarina and was organized by the Federação Catarinense de Surf and the World Surf League Latin America. The competition saw strong performances from various surfers, with Daniella Rosas clinching the South American title and Leo Casal securing the last spot in the Challenger Series.

A study by Procon-SP reveals that 24% of consumers have experienced discrimination in consumer relations, primarily due to financial conditions. The survey, which included 2661 respondents, also highlighted discrimination based on race and gender. Discrimination was most commonly reported in clothing stores, financial institutions, and restaurants. Despite this, a significant number of consumers did not take action against the discrimination they faced. Procon-SP encourages victims to report such incidents to improve consumer services.