Integrated Anatomical and Functional Connectivity Mapping in Episodic Migraine: A Spectral Graph Theory Approach
A study of 14 women with menstrual-related episodic migraine and 15 matched healthy controls combined diffusion-weighted imaging and resting-state fMRI with spectral graph analysis to examine how anatomical communication paths shape brain function. Direct one-step pathways did not differ significantly between groups, while indirect structural walks of four and five steps produced significantly higher structure–function mapping accuracy in patients; these effects survived false-discovery correction and were supported by bootstrap analyses. Patient-specific connectivity alterations were concentrated in Default Mode Network subsystems, particularly DefaultA and DefaultB. The findings suggest that menstrual migraine involves scale-specific changes in mesoscale structure–function integration, although the small, female-only sample, lack of pathway directionality, tractography limitations, and in-sample reconstruction design constrain generalizability.
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Predominantly factual scientific research reporting quantitative methods and results, with cautious interpretation of the findings and acknowledged limitations.